2008-2009
University of Minnesota, Minneapolis, MN, Fellowship in Colon & Rectal Surgery

St. Francis Health System, Mooresville and Indianapolis, IN, Attending Surgeon

Community Hospital South, Indianapolis, IN, Attending Surgeon

Clarian West Hospital, Avon, IN, Attending Surgeon

Indiana University School of Medicine, Indianapolis, IN, Clinical Assistant Professor of Surgery

• 1997 Biological Sciences Honors Research Award, Cornell University
  
• 2004-2006 National Institutes of Health Loan Repayment Program Recipient
  
• 2004 Leonard D. Ensminger Award, Indiana Chapter of the American College of Surgeons
  
• 2004 Surgical Infection Society Resident/Fellow Presentation Award
  
• 2004, 2005 J.K. Berman Essay Awards, Indiana University Department of Surgery
  
• 2005 Carl H. McCaskey Award, Indiana Chapter of the American College of Surgeons
  
• 2005 ACS Region V Committee on Trauma Resident Paper Competition, Basic Science 1st Place
  
• 2008 Alpha Omega Alpha, Indiana University School of Medicine
  

1995
Research Assistant (P.I.: Winston W.Y. Kao, Ph.D.), University of Cincinnati, Cincinnati, OH.
Investigated the effects of reactive oxygen species on apoptosis in injured mouse cornea.

1996-1997
Honors Research Student (P.I.: James B. Russell, Ph.D.), Cornell University, Ithaca, NY.
Examined substrate dependent growth and cell lysis of Streptococcus bovis.

2003-2005
Research Fellow (P.I.: Daniel R. Meldrum, M.D.), Indiana University, Indianapolis, IN.
Investigated inflammatory signaling and vascular reactivity in cardiopulmonary circulation following acute injury.

2009-present
Research Director, St. Francis Cancer Research Foundation, Indianapolis, IN.

2. Bond DR, Tsai BM, Russell JB. Physiological characterization of Streptococcus bovis mutants that can resist 2-deoxyglucose-induced lysis. Microbiology. 1999 Oct; 145(10):2977-2985.

3. Wang M, Tsai B, Brown JW, Meldrum DR. Insulin-like growth factor-1 in myocardial tissue: interaction with tumor necrosis factor. Crit Care. 2003 Dec; 7(6):417-419.

4. Baker L, Meldrum KK, Wang M, Sankula R, Vanam R, Raiesdana A, Tsai B, Hile K, Brown JW, Meldrum DR. The role of estrogen in cardiovascular disease. J Surg Res. 2003 Sep; 115(2):325-344.

5. Tsai BM, Wang M, Turrentine MW, Mahomed Y, Brown JW, Meldrum DR. Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: basic mechanisms to potential therapies. Ann Thorac Surg. 2004 Jul; 78(1):360-368.

6. Wang M, Sankula R, Tsai BM, Meldrum KK, Turrentine M, March KL, Brown JW, Dinarello CA, Meldrum DR. p38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression. Shock. 2004 Feb; 21(2):170-174.

7. Tsai BM, Wang M, March KL, Turrentine MW, Brown JW, Meldrum DR. Preconditioning: evolution of basic mechanisms to potential therapeutic strategies. Shock. 2004 Mar; 21(3):195-209.

8. Wang M, Meng X, Tsai B, Wang JF, Turrentine M, Brown JW, Meldrum DR. Preconditioning up-regulates the soluble TNF receptor I response to endotoxin. J Surg Res. 2004 Sep; 121(1):20-24.

9. Tsai BM, Wang M, Clauss M, Sun P, Meldrum DR. Endothelial monocyte-activating polypeptide II causes NOS-dependent pulmonary artery vasodilation: a novel effect for a proinflammatory cytokine. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R767-R771.

10. Tsai BM, Wang M, Pitcher JM, Meldrum KK, Meldrum DR. Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1215-L1219.

11. Wang M, Tsai BM, Kher A, Baker L, Wairiuko GM, Meldrum DR. The role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H221-H226.

12. Kher A, Wang M, Tsai BM, Pitcher JM, Greenbaum ES, Nagy RD, Patel KM, Wairiuko GM, Markel TA, Meldrum DR. Sex differences in the myocardial inflammatory response to acute injury. Shock. 2005 Jan; 23(1):1-10.

13. Tsai BM, Wang M, Pitcher JM, Kher A, Crisostomo P, Meldrum DR. Zaprinast attenuates hypoxic pulmonary artery injury and causes less aorta relaxation than milrinone. Shock. 2005 Nov; 24(5):417-420.

14. Wang M, Baker L, Tsai BM, Meldrum KK, Meldrum DR. Sex differences in the myocardial inflammatory response to ischemia/reperfusion injury. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E321-E326.

15. Meldrum DR, Wang M, Tsai BM, Kher A, Pitcher JM, Brown JW, Meldrum KK. Intracellular signaling mechanisms of sex hormones in myocardial inflammation and injury. Front Biosci. 2005 May; 10(1):1835-1867.

16. Pitcher JM, Nagy RD, Tsai BM, Wang M, Kher A, Meldrum DR. Is the preconditioning threshold different in females? J Surg Res. 2005 May; 125(2):168-172.

17. Kher A, Meldrum KK, Hile KL, Wang M, Tsai BM, Turrentine MW, Brown JW, Meldrum DR. Aprotinin improves kidney function and decreases tubular cell apoptosis and proapoptotic signaling after renal ischemia/reperfusion. J Thorac Cardiovasc Surg. 2005 Sep; 130(3):662-669.

18. Tsai BM, Wang M, Pitcher JM, Kher A, Brown JW, Meldrum DR. Endothelium-dependent pulmonary artery vasorelaxation is dysfunctional in males but not females following acute lung injury. Surgery. 2005 Jul; 138(1):78-84.

19. Pitcher JM, Tsai BM, Wang M, Kher A, Brown JW, Meldrum DR. Sexual dimorphism in myocardial tumor necrosis factor alpha and cardiac function during endotoxin tolerance. Surgery. 2005 Aug; 138(2):223-228.

20. Nagy RD, Tsai BM, Wang M, Markel TA, Meldrum DR. Stem cell transplantation as a therapeutic approach to organ failure. J Surg Res. 2005 Nov; 129(1):152-160.

21. Pitcher JM, Wang M, Tsai BM, Kher A, Turrentine MW, Brown JW, Meldrum DR. Preconditioning: Gender effects. J Surg Res. 2005 Dec; 129(2):202-220.

22. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-perfusion injury. Cardiovasc Res. 2005 Sep; 67(4):594-603.

23. Wang M, Tsai BM, Turrentine MW, Mahomed Y, Brown JW, Meldrum DR. p38 mitogen activated protein kinase mediates both death signaling and functional depression in the heart. Ann Thorac Surg. 2005 Dec; 80(6):2235-2241.

24. Tsai BM, Turrentine MW, Sheridan BC, Wang M, Fiore AC, Brown JW, Meldrum DR. Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression. Ann Thorac Surg. 2006 Jan; 81(1):272-278.

25. Wang M, Tsai BM, Reiger KM, Brown JW, Meldrum DR. 17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia. J Mol Cell Cardiol. 2006 Feb; 40(2):205-212.

26. Pitcher JM, Wang M, Tsai BM, Kher A, Nelson NT, Meldrum DR. Endogenous estrogen mediates a higher threshold for endotoxin-induced myocardial protection in females. Am J Physiol. 2006 Jan; 290(1):R27-R33.

27. Nelson NT, Mahomed AJ, Pitcher JM, Tsai BM, Wang M, Mahomed Y, Brown JW, Crisostomo P, Meldrum DR. Does Endogenous Testosterone Mediate the Lower Preconditioning Threshold in Males?
J Surg Res. 2006 Mar; 131(1):86-90.

28. Tsai BM, Wang M, Pitcher JM, Kher A, Meldrum DR. Disparate IL-1b and iNOS gene expression in the aorta and pulmonary artery following endotoxemia. Surg Infect. 2006 Feb; 7(1):21-27.

29. Wang M, Tsai BM, Crisostomo PR, Meldrum DR. Tumor necrosis factor receptor 1 signaling resistance in the female myocardium during ischemia. Circulation. 2006 Jul; 114(Suppl 1):I282-289.

30. Morrell ED, Tsai BM, Crisostomo PR, Wang M, Markel TA, Lillemoe KD, Meldrum DR. Therapeutic concepts for hypoxic pulmonary vasoconstriction involving ion regulation and the smooth muscle contractile apparatus. J Mol Cell Cardiol. 2006 Jun; 40(6):751-760.

31. Wang M, Tsai BM, Crisostomo PR, Meldrum DR. Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia. Shock. 2006 May; 25(5):454-459.

32. Markel TA, Crisostomo PR, Wairiuko GM, Pitcher J, Tsai BM, Meldrum DR. Cytokines in necrotizing enterocolitis. Shock. 2006 Apr; 25(4):329-337.

33. Crisostomo PR, Wairiuko GM, Wang M, Tsai BM, Morrell ED, Meldrum DR. Preconditioning versus postconditioning: mechanisms and therapeutic potentials. J Am Coll Surg. 2006 May; 202(5):797-812.

34. Morrell ED, Tsai BM, Crisostomo PR, Hammoud ZT, Meldrum DR. Experimental therapies for hypoxia-induced pulmonary hypertension during acute lung injury. Shock. 2006 Mar; 25(3):214-226.

35. Morrell ED, Tsai BM, Wang M, Crisostomo PR, Meldrum DR. p38 mitogen-activated protein kinase mediates the sustained phase of hypoxic pulmonary vasoconstriction and plays a role in phase I vasodilation. J Surg Res. 2006 Aug; 134(2):335-341.

36. Tsai BM, Patel K, Wang M, Morrell ED, Crisostomo PR, Meldrum DR. Selective protein kinase C inhibition attenuates pulmonary artery cytokine expression without affecting hypoxic pulmonary vasoconstriction. Shock. 2007 Jan; 27(1):36-39.

37. Tsai BM, Lahm T, Morrell ED, Crisostomo PR, Markel T, Wang M, Meldrum DR. Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression. J Surg Res. 2008 Mar; 145(1):130-134.

1. Protein kinase C mediates early and delayed hypoxic pulmonary vasoconstriction. Society of University Surgeons 65th Annual Meeting, St. Louis, MO, Feb. 11-14, 2004.

2. EMAP II causes NOS-dependent pulmonary artery vasodilation: a novel effect for a proinflammatory cytokine. Indiana Chapter ACS Annual Meeting, Bloomington, IN, Apr. 1-3, 2004. Leonard D. Ensminger Award

3. Protein kinase C mediates hypoxic pulmonary vasoconstriction. Surgical Infection Society 24th Annual Meeting, Indianapolis, IN, Apr. 29-May 1, 2004. SIS Resident/Fellow Presentation Award

4. Endothelial monocyte-activating polypeptide II causes pulmonary artery vasodilation via a nitric oxide synthase dependent mechanism. Shock Society 27th Annual Meeting, Halifax, Nova Scotia, June 5-8, 2004.

5. Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. J.K. Berman Essay Program, Indiana University Department of Surgery, Indianapolis, IN, June 18, 2004. Basic Science 1st Place Award

6. Gender-specific effects of p38 mitogen-activated protein kinase activation in myocardial ischemia-reperfusion injury. American College of Surgeons 90th Annual Clinical Congress, Surgical Forum, New Orleans, LA, Oct. 10-14, 2004.

7. Cialis™ causes pulmonary artery vasorelaxation and attenuates catecholamine-induced pulmonary vasoconstriction: a novel long-acting oral alternative to milrinone. Southern Thoracic Surgical Association 51st Annual Meeting, Cancun, Mexico, Nov. 4-6, 2004.

8. Zaprinast attenuates acute hypoxic pulmonary artery cytokine expression and pulmonary vasoconstriction. American Heart Association 2004 Scientific Sessions, New Orleans, LA, Nov 7-10, 2004.

9. Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. Association for Academic Surgery 38th Annual Meeting, Houston, TX, Nov. 11-13, 2004.

10. Endothelium-dependent pulmonary artery vasorelaxation is dysfunctional in males but not females following acute lung injury. Society of University Surgeons 66th Annual Meeting, Nashville, TN, Feb. 9-12, 2005.

11. Effect of gender on endotoxin-induced aortic contractility and inducible nitric oxide synthase expression. Society of University Surgeons 66th Annual Meeting, Nashville, TN, Feb. 9-12, 2005.

12. Aorta and pulmonary artery function and vascular tissue cytokine expression during sepsis. Surgical Infection Society 25th Annual Meeting, Miami, FL, May 5-7, 2005.

13. Female gender protects aorta and pulmonary artery function during sepsis. Indiana Chapter ACS Annual Meeting, Indianapolis, IN, May 12-14, 2005. Carl H. McCaskey Award

14. Gender dimorphism in alpha-agonist therapy and aortic cytokine expression during sepsis. Shock Society 28th Annual Meeting, Marco Island, FL, June 4-7, 2005.

15. Cialis™ (tadalafil), but not Viagra™ (sildenafil) or Levitra™ (vardenafil), inhibits hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression. J.K. Berman Essay Program, Indiana University Department of Surgery, Indianapolis, IN, June 17, 2005. Basic Science 1st Place Award

16. Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and inhibits pulmonary artery cytokine expression. American College of Surgeons 91st Annual Clinical Congress, Surgical Forum, San Francisco, CA, Oct. 16-20, 2005.

17. Gender disparity in arterial reactivity during sepsis and acute lung injury. Region V Committee on Trauma Resident Paper Competition, Detroit, MI, Nov. 10-11, 2005. Basic Science 1st Place Award

18. Selective protein kinase C inhibition attenuates pulmonary artery cytokine expression without affecting hypoxic pulmonary vasoconstriction. Academic Surgical Congress 1st Annual Meeting, San Diego, CA, Feb. 10-14, 2006.

19. Gender disparity in arterial reactivity during sepsis and acute lung injury. American College of Surgeons Committees on Trauma National Resident Paper Competition. Chicago, IL, Apr. 2006.

20. Transanal endoscopic microsurgery (TEM): Outcomes and recommendations. American Society of Colon and Rectal Surgeons Annual Meeting, Hollywood, FL, May 2-6, 2009.

• Physician Information Technology, St. Francis Hospital, Indianapolis, IN
• Pharmacy & Therapeutics, St. Francis Hospital, Indianapolis, IN
• Institutional Review Board, St. Francis Hospital, Mooresville, IN

• American Society of Colon and Rectal Surgeons, Candidate Group
  
• American College of Surgeons, Resident and Associate Society
  
• Association for Academic Surgery, Candidate Group
  
• Society of Gastrointestinal and Endoscopic Surgeons, Candidate Group